Regulation

MOTS-C: Research, Benefits & UK Availability

A mitochondrial-derived peptide researched for metabolic regulation, exercise mimetic effects, and cellular energy homeostasis through AMPK activation.

What is MOTS-C?

MOTS-c is a mitochondrial-derived peptide first described in 2015 and studied for its role in metabolic regulation via AMPK pathway activation.

Research has examined its effects on glucose uptake, insulin sensitivity, fatty acid oxidation, and age-related metabolic decline in preclinical models. MOTS-c nuclear translocation and direct regulation of metabolic gene expression has been investigated as a distinguishing mechanistic feature.

Encoded in the mitochondrial genome rather than nuclear DNA, MOTS-c occupies a unique position in metabolic peptide research. Batch-specific COA included; 99%+ HPLC, independently verified.

Key Research Areas

Mitochondria-derived peptide encoded within the mitochondrial genome — not nuclear DNA like most regulatory peptides

AMPK pathway activation characterised as a primary mechanism; described as an exercise-mimetic in published metabolic research

Glucose uptake and insulin sensitivity examined in preclinical metabolic models under high-fat diet conditions

Nuclear translocation documented — acts directly on metabolic gene regulation rather than through surface receptor signalling

Physical performance and endurance capacity in aged models examined alongside metabolic decline endpoints

Available from Peptify UK

Mots C 10mg

MOTS-C 40mg£84.99

Popular Research Stacks

Metabolic Stack

Pair with NAD+ for comprehensive cellular energy research

How to Store MOTS-C

Unreconstituted (Lyophilised Powder)

Store in a cool, dry place away from direct sunlight. For long-term storage, keep refrigerated at 2–8°C. Under these conditions, lyophilised peptides can remain stable for up to 24 months. For extended preservation beyond 24 months, store at -20°C in a freezer.

Reconstituted (Mixed with BAC Water)

Once reconstituted with bacteriostatic water, the peptide solution must be refrigerated at 2–8°C. Use within 4–6 weeks for optimal potency. Do not freeze reconstituted peptides as this may degrade the compound.

General Tips

Always keep vials upright to prevent leakage. Avoid repeated temperature fluctuations — do not leave vials out at room temperature for extended periods. Protect from light exposure by storing in the original packaging or a dark container. Label all vials with the reconstitution date.

Frequently Asked Questions

What is MOTS-C researched for?

MOTS-C is studied as an exercise mimetic that activates AMPK, enhances glucose uptake, and improves metabolic homeostasis.

What sizes does Peptify offer?

Peptify offers MOTS-C in 10mg and 40mg vials, both at 99%+ purity with COA.

Buy MOTS-C from Peptify UK

99%+ HPLC-verified purity. Full COA. Same-day UK shipping.

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